Reply: Arkham Horror: The Card Game:: Rules:: Re: Are discarded assets, skills and event cards permanently removed from the scenario or campaign?

by Popularculture

Yep.

There are cards that provide benefits that will directly, specifically, say to remove them from your deck and campaign. Otherwise everything gets put into your discard pile and reshuffled for a new draw deck.

This off course excludes cards and investigators that allow you to do hoopy stuff in getting/accessing cards from your discard deck.